Description

Omeprazole + Domperidone Capsule (Under DPCO)

By Monark Biocare – The Trusted Name in Ethical Pharma

Introduction

Gastrointestinal issues are among the most prevalent medical complaints globally, ranging from simple indigestion to chronic conditions like GERD and gastroparesis. In such cases, dual-action medications that address both acid suppression and motility enhancement become essential. Omeprazole + Domperidone Capsules, offered by Monark Biocare, provide a clinically proven, safe, and DPCO-regulated solution to this widespread problem.

This fixed-dose combination, regulated under the Drug Price Control Order (DPCO) by the National Pharmaceutical Pricing Authority (NPPA), ensures affordable access to quality medication without compromising on efficacy or ethical standards.

Composition

• Omeprazole – A Proton Pump Inhibitor (PPI) that reduces gastric acid secretion.
   
• Domperidone – A dopamine antagonist that enhances gastrointestinal motility and prevents nausea and vomiting.
   

This combination is available as delayed-release capsules to maximize therapeutic effectiveness and minimize side effects.

Therapeutic Class

• Antiulcerant / Antiemetic / Prokinetic Agent
   

Uses of Omeprazole + Domperidone Capsules

This combination is indicated for a wide range of digestive tract disorders, including:

1. Gastroesophageal Reflux Disease (GERD)

• Reduces stomach acid and enhances esophageal clearance
   
• Controls symptoms like heartburn, regurgitation, and chest discomfort
   

2. Functional Dyspepsia

• Relieves bloating, early satiety, nausea, and post-meal fullness
   
• Improves appetite and digestion in chronic dyspepsia patients
   

3. Peptic Ulcer Disease

• Heals and prevents recurrence of stomach and duodenal ulcers
   
• Useful in H. pylori eradication regimens
   

4. Gastroparesis (Delayed Gastric Emptying)

• Increases gastric motility and enhances the passage of food from the stomach
   
• Effective in patients with diabetes-related digestive issues
   

5. Nausea and Vomiting Associated with Acid Disorders

• Domperidone acts centrally and peripherally to control nausea
   

6. NSAID-Associated Gastritis

• Protects the stomach lining from damage caused by painkillers
   

How it works?

• Omeprazole blocks the H+/K+ ATPase enzyme in gastric parietal cells, effectively shutting down the acid "pump" at the final stage of acid production.
   
• Domperidone blocks dopamine receptors in the gut and brain, promoting gastric emptying and preventing nausea and vomiting.
   

Together, this dual-action therapy provides complete gastrointestinal relief by addressing both acid production and gastric motility.

Dosage & Administration

• Typical Dose: 1 capsule daily, taken 30 minutes before meals
   
• Route: Oral, swallowed whole with water
   
• Duration: 2–8 weeks depending on the medical condition
   

Always use under the guidance of a healthcare professional.

Side Effects

While generally well tolerated, some patients may experience:

Common Side Effects:

• Headache
   
• Dry mouth
   
• Abdominal discomfort
   
• Diarrhea or constipation
   
• Flatulence
   

Less Common but Serious:

• Galactorrhea (milk production)
   
• Gynecomastia (breast enlargement in males)
   
• Menstrual irregularities (in long-term use)
   
• Dizziness or drowsiness
   
• Altered liver function (rare)
   
• Cardiac arrhythmias (very rare, linked to prolonged QT interval)
   

Note: Long-term use should be monitored by a physician, particularly for electrolyte imbalances or hormonal effects from Domperidone.

Precautions and Contraindications

• Not recommended in patients with known hypersensitivity
   
• Avoid in people with prolactin-related tumors
   
• Use cautiously in liver impairment
   
• Should not be used with potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
   

Drug Interactions

• Clopidogrel – Reduced antiplatelet effect with Omeprazole
   
• Ketoconazole / Itraconazole – Absorption may decrease with increased pH
   
• Antacids – May interfere with the capsule’s enteric coating
   
• Macrolide antibiotics and antifungals – Increase Domperidone levels
   

Pregnancy and Lactation

• Pregnancy Category C – Use only if clearly needed
   
• Lactation – Domperidone is excreted in breast milk; use only if advised by a doctor
   

Storage

• Store in a cool, dry place below 25°C
   
• Protect from moisture and direct sunlight
   
• Keep out of reach of children
   

Why Omeprazole + Domperidone is Under DPCO

This combination is regulated under the Drug Price Control Order (DPCO), ensuring fair pricing for essential medications in India. The NPPA routinely updates the ceiling price for this combination to prevent overpricing.

Benefits of DPCO Compliance:

• Ensures affordability for patients
   
• Builds ethical brand reputation
   
• Encourages prescriptions from doctors aware of price-sensitive patients
   
• Makes products eligible for inclusion in government supply chains and public health schemes
   

Franchise & PCD Opportunities with Monark Biocare

About Monark Biocare

Monark Biocare is a trusted pharmaceutical company dedicated to providing high-quality, affordable medicines across India. With a robust portfolio spanning gastro, neuro, cardio, and more, Monark is a preferred partner for pharma franchises and PCD entrepreneurs.

Franchise Opportunities for Omeprazole + Domperidone

We offer exclusive franchise rights for this fast-moving combination under our established brand umbrella.

✅ Monopoly-Based Franchise Rights

Secure your district or region with no internal competition

✅ WHO-GMP Certified Manufacturing

All products, including Omeprazole + Domperidone, are made under stringent quality standards

✅ DPCO Compliant Pricing

Stay compliant with pricing laws while maintaining healthy margins

✅ Promotional Support

Get MR bags, visual aids, product cards, samples, visiting cards, and more

✅ Fast Dispatch & Logistic Support

Pan-India delivery with real-time stock updates

✅ Transparent Policies

No hidden charges, ethical business practices, and complete franchise support

Who Can Join?

• Pharma professionals looking to start their own business
   
• Distributors seeking product diversification
   
• Existing PCD players aiming to expand their range
   
• Doctors, chemists, and medical representatives with local influence
   

How to Partner with Monark Biocare

1. Contact us with your region of interest
    
2. Choose from our product range including Omeprazole + Domperidone
    
3. Receive promotional materials and samples
    
4. Launch your brand with confidence
    
5. Grow with our dedicated support and repeat prescriptions
    

Final Thoughts

Omeprazole + Domperidone Capsules are a powerful and essential combination in today’s prescription landscape. Backed by science and supported by regulation (DPCO), this medication offers a safe, effective, and economically viable solution for patients suffering from gastric disorders.

Monark Biocare brings this essential therapy to you with a promise of quality, compliance, and commercial success.