Description

Dextromethorphan HBr + Phenylephrine + Chlorpheniramine Capsules

Seasonal changes, pollution, and viral infections often lead to an uncomfortable combination of cold, cough, nasal congestion, sneezing, and throat irritation. These symptoms can interrupt daily activities, reduce sleep quality, and affect overall well-being.

For patients seeking complete symptomatic relief, a single-ingredient remedy often falls short. That’s where Dextromethorphan HBr + Phenylephrine + Chlorpheniramine Capsules step in — a powerful triple-action combination developed to target multiple cold-related symptoms in one convenient capsule.

Whether it's a seasonal flu, allergic rhinitis, or a viral upper respiratory tract infection, this combination capsule provides fast and effective symptom control without the need for multiple medications.

Composition

Each capsule contains:

• Dextromethorphan Hydrobromide – 10 mg
   
• Phenylephrine Hydrochloride – 5 mg
   
• Chlorpheniramine Maleate – 2 mg
   

These three agents work synergistically to deliver antitussive, decongestant, and antihistamine effects, making this capsule an all-in-one solution for cold and flu-like symptoms.

Mechanism of Action

 Dextromethorphan HBr – Antitussive

Dextromethorphan is a centrally acting cough suppressant. It acts on the cough center in the medulla to elevate the threshold for coughing, thereby reducing the urge to cough. Unlike codeine, it is non-narcotic, non-addictive, and well-tolerated for short-term use.

 Phenylephrine HCl – Nasal Decongestant

Phenylephrine is a selective alpha-1 adrenergic receptor agonist. It causes vasoconstriction in nasal mucosa, thereby reducing swelling and allowing air to flow more freely through the nasal passages. This results in rapid relief from nasal stuffiness and sinus pressure.

 Chlorpheniramine Maleate – Antihistamine

Chlorpheniramine is a first-generation H1-antihistamine. It effectively reduces symptoms like sneezing, watery eyes, runny nose, and itching, by blocking the effects of histamine. It also has a mild sedative effect, which can aid sleep and comfort during illness.

Therapeutic Indications

This triple-combination capsule is indicated for the symptomatic relief of:

• Dry or irritating cough
   
• Common cold
   
• Allergic rhinitis
   
• Sinus congestion and pressure
   
• Sneezing and rhinorrhea
   
• Upper respiratory tract infections (URTIs)
   
• Seasonal flu symptoms
   

It is especially useful in conditions where multiple symptoms coexist, such as cough with nasal congestion and sneezing.

Key Benefits

 Triple Symptom Control

One capsule targets cough, congestion, and allergy symptoms together—eliminating the need for separate medications.

 Non-Drowsy Daytime Use

At the recommended dosage, this combination offers minimal sedation, making it safe for daytime use in most adults.

 Fast-Acting & Long-Lasting

The formulation ensures rapid onset of action, typically within 30 minutes, and offers 4–6 hours of relief per dose.

 Convenient Capsule Form

Capsules are easy to swallow, portable, and do not require refrigeration, making them ideal for travel or on-the-go relief.

Dosage & Administration

• Adults and children over 12 years:
  1 capsule every 4–6 hours as needed
  Maximum: 4 doses in 24 hours
   
• Children under 12 years:
  Use only if prescribed by a physician.
   
• Route: Oral, with or without food.
  Note: Drink plenty of fluids to help loosen mucus and enhance the effect.

Precautions & Warnings

• Not to be used in combination with MAO inhibitors or within 14 days of stopping such treatment.
   
• Avoid in patients with:
   
  • Severe hypertension
     
  • Coronary artery disease
     
  • Thyroid disorders
     
  • Glaucoma
     
• Use caution in patients with prostatic hypertrophy, asthma, or liver dysfunction.
   
• May cause mild drowsiness in sensitive individuals; avoid driving or operating machinery if affected.
   
• Consult a physician before using during pregnancy or lactation.

Adverse Effects

Generally well-tolerated. Common, usually mild, side effects may include:

• Dry mouth or throat
   
• Mild dizziness or drowsiness
   
• Nervousness or restlessness
   
• Gastrointestinal upset (nausea or constipation)
   

Serious side effects are rare but require immediate medical attention if they occur (e.g., allergic reactions, rapid heartbeat, difficulty urinating).

Pharmacokinetics Overview

• Dextromethorphan: Peak effect in 2–3 hours, hepatic metabolism via CYP2D6, excreted renally.
   
• Phenylephrine: Rapid absorption, low bioavailability due to first-pass metabolism, peak effect within 1–2 hours.
   
• Chlorpheniramine: Onset in 30–60 minutes, duration up to 6 hours, hepatic metabolism.
   

The combination works well for acute short-term use and is not intended for chronic cough management.

Drug Interactions

• May enhance sedative effects of alcohol or CNS depressants.
   
• Use caution with other antihypertensives, antidepressants, or cough medications.
   
• Check labels of other OTC cold medicines to avoid ingredient duplication.

Packaging & Storage

• Supplied in blister packs of 10 or 15 capsules
   
• Store below 25°C, in a dry place, away from direct sunlight and moisture.
   
• Keep out of reach of children.

Market Demand

With increasing exposure to pollution, allergens, and viruses, multi-symptom cold medications are in high demand. This capsule combination is ideal for:

• Retail pharmacies
   
• Hospital OPDs
   
• Travel and first-aid kits
   
• Workplace health packs
   

Its broad utility and affordability make it a staple in general practice and over-the-counter (OTC) settings.

Conclusion

Dextromethorphan HBr + Phenylephrine + Chlorpheniramine Capsules provide a comprehensive, fast-acting, and safe solution for managing the most common and bothersome symptoms of cold, cough, and allergies. Their synergistic mechanism, ease of use, and widespread applicability make them a go-to choice for clinicians and consumers alike.

For those facing dry cough, nasal congestion, and allergic sneezing all at once, this triple-action capsule is the right remedy at the right time.